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In a mouse model in which young mice are simultaneously exposed to antibiotics and a high-fat (HF) diet, Lactobacillus species regulate intestinal epithelial cells (IECs) to limit diet-induced obesity during early life.
A Lactobacillus-derived metabolite, Phenyllactic acid (PLA), protects against metabolic dysfunction caused by early-life exposure to antibiotics and a HF diet by increasing the abundance of peroxisome proliferator-activated receptor gamma (PPAR-g) in IECs of the [small intestine](brain://eV4lBJ19WEiPIy46-1cX_Q/SmallIn…