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NCT01908426 - CELESTIAL - 2nd line - Cabozantinib vs Placebo in Hepatocellular Carcinoma (HCC) Who Have Received Prior Sorafenib

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Conclusion: Among patients with previously treated advanced hepatocellular carcinoma, treatment with cabozantinib resulted in longer overall survival and progression-free survival than placebo. The rate of high-grade adverse events in the cabozantinib group was approximately twice that observed in the placebo group.
Sim & Knox 2018 Curr Probl Cancer 42: 40