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Staphylococcus aureus
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Staphylococcus aureus is a tough germ known for being hard to kill with antibiotics and having many ways to cause disease. These include making toxins, forming protective layers called biofilms, and avoiding the immune system.
Anti-virulence strategies are:
- Stopping the bacteria from sticking to surfaces and forming biofilms
- Neutralizing the toxins it produces
- Interrupting its communication system (like using Agr system blockers)
- Preventing it from getting iron, which it needs to grow
The high-priority pathogen list features Staphylococcus aureus along with its resistant…
References (Sources)
- Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001–2004
- Disarming Staphylococcus aureus: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence
- Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
- Intracellular Staphyloccus aureus - A Mechanism for the indolence of Osteomyelitis
- Invited review: The role of cow, pathogen, and treatment regimen in the therapeutic success of bovine Staphylococcus aureus mastitis
- Mitochondrial calcium uniporter affects neutrophil bactericidal activity during Staphylococcus aureus infection
- Suppression of Staphylococcus aureus superantigen-independent interferon gamma response by a probiotic polysaccharide