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Maturation of Dendritic Cells (DCs) goes along with increased IL-12 production
The maturation of dendritic cells (DCs) is crucial for initiating immune responses.
A single intravenous (i.v.) injection of Alfa-galactosylceramide (alfa-GalCer) induced full maturation of splenic DCs within 4 hours in mice. Maturation was evidenced by: Increased expression of costimulatory molecules and MHC class II / HLA class II human, Production of [interferon-gamma](brain://jJh19XffL0-DbX5y…