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Dendritic Cells (DCs) maturation
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Maturation of Dendritic Cells (DCs) goes along with increased IL-12 production
The maturation of dendritic cells (DCs) is crucial for initiating immune responses.
A single intravenous (i.v.) injection of Alfa-galactosylceramide (alfa-GalCer) induced full maturation of splenic DCs within 4 hours in mice. Maturation was evidenced by: Increased expression of costimulatory molecules and MHC class II / HLA class II human, Production of [interferon-gamma](brain://jJh19XffL0-DbX5y…
References (Sources)
- Activation of Natural Killer T Cells by -Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein
- Dendritic cells and the control of immunity
- EFFICIENT ANTITUMOR IMMUNITY DERIVED FROM MATURATION OF DENDRITIC CELLS THAT HAD PHAGOCYTOSED APOPTOTIC/NECROTIC TUMOR CELLS
- IL-1ß Enhances CD40 Ligand-Mediated Cytokine Secretion by Human DC: A Mechanism for T Cell-Independent DC Activation
- Plasmacytoid dendritic cells produce cytokines and mature in response to the TLRT agonists, imiquimod and resiquimod
- Strategies to discover regulatory circuits of the mammalian immune system
- The role of intestinal bifidobacteria on immune system development in young rats