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Enteric Glial Cells (EGCs) are a diverse and adaptable group of cells found in the gastrointestinal tract. Their characteristics vary based on their specific location within the gut wall and the current physiological condition of the enteric nervous system (ENS) (1, 2, 3). Mucosal enteric glial cells are an essential component of the ENS in the intestine (1, 5, 8).
Glial cells of the enteric nervous system form a vast and abundant network spreading throughout all the layers of the gastrointestinal wall (7). Intrinsic primary afferent neurons, interneurons, and motor neurons are surrounded by 1–7 times as many enteric glial c…