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Exfoliative toxins (ETs) are virulence factors produced by certain strains of Staphylococcus aureus and Staphylococcus hyicus. These toxins are responsible for causing a variety of skin conditions by disrupting the integrity of the epidermis.
Exfoliative toxins are serine proteases that specifically target Desmoglein 1 (Dsg1), a protein critical for cell-cell adhesion in the superficial layers of the epidermis. By cleaving Dsg1, these toxins caus…