meRfi®-GM
2′3′-cyclic GMP-AMP (cGAMP)
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Contents
In humans, binding of cGAMP to the STING receptor initiates the type I interferon response
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References (Sources)
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- STING is a direct innate immune sensor of cyclic di-GMP