NCT03477916 - Fecal Microbiota Transplantation (FMT) + High-fermentable (HF) fibers vs Fecal Microbiota Transplantation (FMT) + Low-fermentable (LF) fibers vs High-fermentable (HF) fibers vs Low-fermentable (LF) fibers & Metabolic syndrome (MetS)

Background

Fecal microbial transplantation (FMT) from lean donors to patients with obesity has shown potential metabolic benefits; however, the results have been inconsistent (1)

Study overview

It is a randomized clinical phase II treatment trial studying Fecal Microbiota Transplantation (FMT) + High-fermentable (HF) fibers vs Fecal Microbiota Transplantation (FMT) + Low-fermentable (LF) fibers vs High-fermentable (HF) fibers vs Low-fermentable (LF) fibers in seventy randomized participants with Metabolic syndrome (MetS) (1)

Primary outcome measures

Insulin sensitivity (HOMA2-IR)

Results

• FMT-LF Group:
  
  
  • Significant improvement in HOMA2-IR after 6…