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In humans, beta-glucuronidase expression by human gut Enterobacteriaceae decreases the indomethacin concentration in-vitro.
The inhibition of bacterial beta-glucuronidase plays a protective role in mice against enteropathy, which is induced by certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin.
see also:
[Beta-glucuronidases & Xe…