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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Colitis-Associated Colorectal Cancer (CAC)

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Colitis-Associated Colorectal Cancer (CAC) is a specific type of colorectal cancer that develops in patients with inflammatory bowel disease (IBD), particularly ulcerative colitis (UC) and Crohn's disease (CD)
Yu 2018
Muller et al. 2020c
Chattopadhyay et al. 2021 Applied Biochemistry and Biotechnology 193:1780-1799
Zhang et al. 2023i Front Immunol. 14: 1103617

Approx. 2% of Colorectal Cancer (CRC) is linked to pre-existing inflammation known as Colitis-Associated Colorectal Cancer (CAC), but most develops in pts without underlying [infla…

References (Sources)

Adenoma-linked barrier defects and microbial products drive IL-23/ IL-17-mediated tumor growth
Grivennikov et al. 2012 Nature 491(7423): 254-258
Blockade of IDO-kynurenine-AhR axis a rated colitis-associated colon cancer via inhibiting immune tolerance
Zhang et al. 2021 Cell Mol Gastroenterol Hepatol 12: 1179-1199
Cancer-promoting effects of microbial dysbiosis
Sheﬂin et al. 2014 Curr Oncol Rep. 16(10): 406
Exploring the Role of Gut Microbiome in Colon Cancer
Chattopadhyay et al. 2021 Applied Biochemistry and Biotechnology 193:1780-1799
Review
Intestinal FXR Activation via Transgenic Chimera or Chemical Agonism Prevents Colitis-Associated and Genetically-Induced Colon Cancer
Cariello et al. 2022 Cancers (Basel) 14(13): 3081
Novel regulatory roles of Wnt1 in infectionassociated colorectal cancer
Wang et al. 2018g Neoplasia 20: 499-509
Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer
Zhang et al. 2023i Front Immunol. 14: 1103617
Review

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5/29/2026

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Colitis-Associated Colorectal Cancer (CAC)

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