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A double-blind, non-randomized treatment trial (crossover assignment) to assess the efficacy of Lactococcus lactis W136 (topical application) in adults with Chronic Rhinosinusitis
Primary outcome measures:
Sino-nasal symptom score
Conclusion:
After applying live bacteria to the diseased sinus epithelium, gene expression profiling reveals the involvement of various components of the inflammation-microbiome-epithelial barrier axis in chronic rhinosinusitis (CRS). These effects seem to encompass both the restoration of the epithelium and the modulation of innate and adaptive immunity. This supports the potential interest in tar…