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T Cell Development
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Contents
T cell development relies on successfully rearranging T-Cell Receptor (TCR) gene loci encoding antigen-specific receptors. The Recombination-activating gene (RAG) 2 is required for TCR gene rearrangements at specific T cell development stages.
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References (Sources)
- A cell atlas of human thymic development defines T cell repertoire formation
- Human T Cell Development, Localization, Function throughout Life
- Lymphoid cell development from fetal hematopoietic progenitors and human pluripotent stem cells
- T-cell receptor β-selection is required at the CD4+CD8+ stage of human T-cell development