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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Crohn's disease (CD) & NLRP3 Inflammasome

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Decreased expression of the NLRP3 Inflammasome has been recently associated with susceptibility to Crohn's disease (CD). However, its role in colitis has not been well characterized until now.
Zaki et al. 2020 Immunity 32: 379-391

Our research shows that mice deficient in NLRP3 Inflammasome or the inflammasome effectors ASC and caspase-1 are highly susceptible to dextran sodium sulfate (DSS)-induced colitis. Defective inflammasome activation leads to:

Loss of epithelial integrity

Systemic dispersi…

References (Sources)

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
Bauer et al. 2010 Gut 59: 1192-1199
The NLRP3 inﬂammasome protects against loss of epithelial integrity and mortality during experimental colitis
Zaki et al. 2020 Immunity 32: 379-391

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5/29/2026

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Crohn's disease (CD) & NLRP3 Inflammasome

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