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Regulatory T cells (Tregs) maintain self-tolerance and immunological homeostasis. Tregs can subvert anti-cancer immune surveillance in healthy individuals. Consequently, Tregs contribute to tumor development and progression in various cancers. Therefore, Tregs are considered a crucial therapeutic target in cancer immunotherapy.
Tregs are abundant in both inflamed and non-inflamed tumors. It is assumed that Tregs have different accumulation, activation, and survival mechanisms in the [Tumor Microenvironment (TME)](brain://iNKwGFKamFeU8HiEArQkGQ/TumorMicroenvironmentT…