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The Digital Textbook on Gut Microbiota and Beyond
Alzheimer's disease (AD) & Gut microbiota
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Contents
Antibiotics and germ-free housing can change the gut microbiota. Dysbiosis can affect Alzheimer's disease (AD) pathologies. Broad-spectrum antibiotics reduce amyloid-beta plaque in certain mouse models. These models include APP/PS1, APPPS1-21, and 5XFAD.
Dodiya et al. 2021 J Exp Med…
References (Sources)
- Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence
- Gut microbiome-derived metabolites in Alzheimer's disease: Regulation of immunity and potential for therapeutics
- Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
- Host microbiota constantly control maturation and function of microglia in the CNS
- The gut microbiome in Alzheimer's disease: what we know and what remains to be explored
- The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
- The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease