Fecal Microbiota Transplantation (FMT) & Inflammatory Bowel Disease (IBD)

Fecal Microbiota Transplantation (FMT) may increase the proportion of people with active UC who achieve clinical and endoscopic remission. The evidence was very uncertain about whether use of FMT in people with active UC impacted the risk of serious adverse events or improvement in quality of life. The evidence was also very uncertain about the use of FMT for maintenance of remission in people with UC, as well as induction and maintenance of remission in people with CD, and no conclusive statements could be made in this regard. Further studies are needed to address the beneficial effects and safety profile of FMT in adults and children with active UC and CD, as well as its potential to promote longer‐term maintenance of remission in UC and CD
Imdad et al. 2018 Cochrane Database Syst. Rev. 11: CD012774

Fecal microbial transplantation is still considered an experimental procedure and has not been approved by the FDA for the treatment of IBD. Nonetheless, off-label use of FMT in IBD patients does occur.
Chande et al. 2020 Inflamm Bowel Dis 26: 843-851

A literature search found only randomized clinical trials for the treatment of ulcerative colitis using FMT; none for FMT in Crohn's disease
Chande et al. 2020 Inflamm Bowel Dis 26: 843-851

In contrast to CDI, where FMT successfully treats >90% of cases (Quraishi et al. 2017 Aliment Pharmacol Ther 46: 479-93 ; van Nood et al. 2013 N Engl J Med 368: 407-15), FMT application in IBD faces significant challenges complex disease etiology and the absence of a clear microbial target
Leonardi et al. 2020 Cell Host & Microbe 27: 823-829

Several studies demonstrating the efficacy and safety of FMT for induction of remission in IBD were summarized in a recent Cochrane review
Imdad et al. 2018 Cochrane Database Syst. Rev. 11: CD012774

A number of studies have looked at FMT as a treatment for IBD, but with conflicting results
Sidhu & van der Poorten 2017 Aust Fam Physician 46: 206–211

see also:
Application & Fecal Microbiota Transplantation (FMT)
Fecal Microbiota Transplantation (FMT) & Crohn’s Disease (CD)
Fecal Microbiota Transplantation (FMT) & Preclinical/Clinical data
Fecal Microbiota Transplantation (FMT) & Ulcerative Colitis (UC)
NCT02390726 - Fecal Microbiota Transplantation (FMT) & Ulcerative Colitis (UC)
RBX2660 & Inflammatory Bowel Disease (IBD)