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Circulating tumor DNA (ctDNA) enables real-time cancer genomic profiling without tissue biopsy. ctDNA-based technology can support patient treatment from diagnosis to advanced disease. In metastatic disease, ctDNA can identify somatic mutations, copy number variants (CNVs), and structural rearrangements that predict response to therapy. However, the ctDNA percentage (ctDNA%) is unpredictable, complicating variant detection strategies. Test design also influences which types of genomic alterations are identifiable.
Deeper and broader sequencing of circulating tumor DNA (ctDNA) has identified a wealth of cancer markers in the circulation
Circulating tumor DNA (ctDNA) is free [DNA](brain://P-hxRRUCMEq…