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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Guanine nucleotide-binding coupling proteins (G-proteins)

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Heterotrimeric G proteins function to convert extracellular signals recognized by G protein-coupled receptors (GPCRs) into intracellular signaling events.
Ellaithy et al. 2020 TIBS 45: 1049

G proteins selectively stabilize a dynamic ensemble of conformations G-protein coupled receptors (GPCRs)
Manglik et al. 2015 Cell 161(5): 1101-1111
Gregorio et al. 2017 Nature 547(7661): 68-73
Latorraca et al. 2017 Chem Rev 117(1): 139-155
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References (Sources)

GPCR Dynamics: Structures in Motion
Latorraca et al. 2017 Chem Rev 117(1): 139-155
Review
Single-molecule analysis of ligand efficacy in beta2AR-G-protein activation
Gregorio et al. 2017 Nature 547(7661): 68-73
Structural and Biophysical Mechanisms of Class C G Protein Coupled Receptor Function
Ellaithy et al. 2020 TIBS 45: 1049
Review
Structural Insights into the Dynamic Process of beta2-Adrenergic Receptor Signaling
Manglik et al. 2015 Cell 161(5): 1101-1111

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5/29/2026

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Guanine nucleotide-binding coupling proteins (G-proteins)

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