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Worldwide, head and neck carcinomas account for 5% of all malignancies. Unfortunately, two-thirds of patients relapse after initial multimodal therapy. Until early 2010, the median overall survival (OS) of metastatic patients was approximately 10 months.
Head and neck cancer is the seventh most common type of cancer worldwide, comprising a diverse group of tumors that affect the upper aerodigestive tract. Although many different histologies exist, the most common type is Head & Neck squamous cell carcinoma (HNSCC)
Head and neck cancer includes tumors that develop in the: