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T cell development & Thymus
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Contents
The thymus provides the microenvironment essential for the development of T cells from hematopoietic stem cells (HSCs)
The use of 3D fetal thymic organ cultures () and the 2D OP9 stromal cell system expressing the Notch ligand Delta-like 1 (DLL1) () has facilitated greatly our understanding of the in vitro development of T cells from hematopoietic precursors
T cells are developed in the thymus where a microenvironment is set, which enables the selection of T cell receptors (TCRs) to generate a diverse repertoire of potential antigen recognition
Koch & Radtke 2…
References (Sources)
- Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
- Mechanisms of T cell development and transformation.
- Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1
- T-cell differentiation in thymus organ cultures
- Zoned out: functional mapping of stromal signaling microenvironments in the thymus