Fecal Microbiota Transplantation (FMT) & Immune Checkpoint Inhibitor-Associated Colitis / Intestinal inflammation (ICIAC)

In conclusion, Fecal Microbiota Transplantation (FMT) resulted in improvement of Immune checkpoint inhibitor-associated Colitis / Intestinal inflammation (ICIAC) symptoms and corresponding microbial changes in 2 cancer patients with refractory Immune Checkpoint Inhibitor-Associated Colitis (ICIAC). While more research is warranted, microbiome-modulation could be a promising new therapeutic option for Immune Checkpoint Inhibitor-Associated Colitis (ICIAC) .
Groenewegen et al. 2023 Journal of Immunotherapy 46(6): 216-220

ICI-associated colitis successfully treated with fecal microbiota transplantation (FMT), with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T cells (Tregs) within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis
Wang et al. 2018d Nat Med. 24: 1804–1808