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Dihydroprogesterone (DHP) is a 5alfa-reduced metabolite of progesterone with significant progestin activity in some mammals, such as horses, where it can sustain pregnancy without circulating progesterone. In vertebrates, DHP and similar neuroactive metabolites, like tetrahydroprogesterone, play crucial roles in modulating neurobiological processes, including stress, neuroprotection, and analgesia.
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