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While Farnesoid X receptor (FXR / NR1H4) and Takeda G-Protein-Coupled Receptor 5 (TGR5 ; BG37 ; GBPAR1) present promising targets for modulating glucose metabolism through bile acid physiology, the safety and efficacy of these approaches require further validation. The established treatments, such as ASBT inhibitors, bile acid sequestrants, and metformin, continue to offer valuable insights and potential for optimization in the context of g…