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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Antibiotic persistence

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Antibiotic persisters are bacterial cells that endure bactericidal antibiotic treatment despite being genetically sensitive.
Bigger 1944 Lancet 244: 497-500
Balaban et al. 2004 Science 305: 1622-1625
Balaban et al. 2019 Nat. Rev. Microbiol. 17: 441–448

Antibiotic Persisters are categorized by their generation pathways:

starvation-triggered,

spontaneously generated,

antibiotic-induced.
However, their molecular mechanisms remain unclear.

Balaban et al. 2019 Nat. Rev. Microbiol. 17: 441–448

Persistence can arise from nutrient deprivation (Fung et al. 2010 Antimicrob Agents Chemother 54: 1082-1093) through the accumulation of the Alarmones (Korch et al. 2003 Mol Microbiol 50: 1199-1213; Nguyen et al. 2011 Science 334: 982-986; Kaspy et al. 2013 Nat Commun…

References (Sources)

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Bullman et al. 2017
Bacterial persistence as a phenotypic switch
Balaban et al. 2004 Science 305: 1622-1625
Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence
Van den Bergh et al. 2016 Nat. Microbiol. 1: 16020
HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase
Kaspy et al. 2013 Nat Commun 4: 3001
hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis
Moyed & Bertrand 1983 J Bacteriol 155: 768-775
Ranking of persister genes in the same Escherichia coli genetic background demonstrates varying importance of individual persister genes in tolerance to different antibiotics
Wu et al. 2015 Front. Microbiol. 6: 1003
The widely used antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo
Westfall et al. 2019 Antimicrob Agents Chemother 63: e02312-18

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