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Antibiotic persistence
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Contents
Antibiotic persisters are bacterial cells that endure bactericidal antibiotic treatment despite being genetically sensitive.
Antibiotic Persisters are categorized by their generation pathways:
- starvation-triggered,
- spontaneously generated,
- antibiotic-induced.
However, their molecular mechanisms remain unclear.
Persistence can arise from nutrient deprivation () through the accumulation of the Alarmones (; ; Kaspy et al. 2013 Nat Commun…
References (Sources)
- Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
- Bacterial persistence as a phenotypic switch
- Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence
- HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase
- hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis
- Ranking of persister genes in the same Escherichia coli genetic background demonstrates varying importance of individual persister genes in tolerance to different antibiotics
- The widely used antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo