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Antibiotic persistence
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Contents
Bacterial cells in an isogenic population may exhibit phenotypic differences, allowing them to survive some stressors such as antibiotics. This survival may occur through antibiotic persistence, in which a subset of cells transition to an inactive, drug-tolerant state without resistance genes, leading to slower elimination and eventual relapse of infection. Persistence is observed in biphasic killing curves.
References:
see also:
Antibiotics & Pathogenic Bacteria
[Antibiotic tolerance](brain://KnjGg3JjMUSemf21cVGuTg/Antib…
References (Sources)
- Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
- Distinguishing between resistance, tolerance and persistence to antibiotic treatment
- Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence
- Molecular Mechanisms Underlying Bacterial Persisters
- Persisters: a distinct physiological state of E. coli
- Ranking of persister genes in the same Escherichia coli genetic background demonstrates varying importance of individual persister genes in tolerance to different antibiotics
- Stochastic pulse regulation in bacterial stress response