Adiposity / Obesity & Drugs / Treatments

Usually, the primary objective in obesity or adiposity trials is to show that an intervention produces clinically meaningful, sustained reduction in body weight or excess adiposity versus control.

Pharmacological treatments for obesity serve as a valuable addition to lifestyle interventions. These interventions frequently result in only modest weight loss, which can be challenging to sustain.
Bergmann et al. 2023 Diabetes Obes Metab 25(1): 18-35

Manipulation of the gut microbiota alone is insufficient to alter bodyweight
Boscaini et al. 2022 Molecular Metabolism 57: 101427

Lifestyle modifications remain the primary therapy for obesity and related metabolic disorders.
Cerdó et al. 2019

Increased fruit and vegetable intake results in a greater reduction of weight than limited intake of high-fat low-nutrient-dense foods with controlled physical activity
Epstein et al. 2001 Obes Res. 9: 171-8