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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Anti-tumor T Cell Function

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Anti-tumor T cell function specifically refers to the activity of cytotoxic and helper T lymphocytes directed against tumor cells.

Cytotoxic T cell (CTL) directly recognize tumor antigens presented by MHC class I molecules and induce apoptosis of malignant cells through perforin–granzyme and Fas–FasL pathways (1).

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
Matsushita et al. 2012 Nature 482: 400-404
Checkpoint blockade cancer immunotherapy targets tumour-speciﬁc mutant antigens
Gubin et al. 2014
Expression of tumour-specific antigens underlies cancer immunoediting
DuPage et al. 2012 Nature 482: 405-409
MHC-II neoantigens shape tumour immunity and response to immunotherapy
Alspach et al. 2019 Nature 574: 696-701
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
Robbins et al. 2013 Nat. Med. 19: 747-752
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens
Lennerz et al. 2005 Proc. Natl Acad. Sci. USA 102: 16013-16018

5/29/2026