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Allogeneic T cell expansion is the primary determinant of graft-versus-host disease (GVHD). The current understanding is that this expansion is driven by histocompatibility antigen disparities between donor and recipient. This paradigm represents a closed genetic system where donor T cells interact with peptide-major histocompatibility complexes (MHCs).
Graft versus host disease (GVHD) is a post-transplant condition where donor T cells attack recipient tissues, traditionally viewed as an immunological issue requiring immunosuppressive treatment
Graft-Versus-Host Disease (GVHD) is traditionally divided into an acute and a chronic disease (see also: [Graft-Vers…