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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Leptin

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Leptin (from Greek λεπτός leptos, "thin") is a hormone predominantly made by adipocytes and enterocytes in the small intestine that helps to regulate energy balance by inhibiting hunger, which in turn diminishes fat storage in adipocytes

Leptin regulates food intake and energy expenditure
López-Moreno et al. 2020 Nutrients 12: 1921

[Obese](brain://cI3xvLzvcESFJ5zXNDvWXw/Adipos…

Diet-induced obese mice develop peripheral, but not central, resistance to leptin
Van Heek et al. 1997 J Clin Invest 99: 385-390
Different Central and Peripheral Responses to Leptin in Rhesus Monkeys: Brain Transport May Be Limited
Ramsey et al. 1998 J Clin Endocrinol Metab 83: 3230-3235
Intranasal Leptin Reduces Appetite and Induces Weight Loss in Rats with Diet-Induced Obesity (DIO)
Schulz et al. 2012 Endocrinology 153: 143-153
Leptin and the Blood-Brain Barrier: Curiosities and Controversies
Banks 2021 Compr Physiol 11: 2351-2369
Review
Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis
López-Moreno et al. 2020 Nutrients 12: 1921
Meta-Analysis
Review
Protein appetite is increased after central leptin-induced fat depletion
Wiater et al. 2007 Am J Physiol Regul Integr Comp Physiol 293: R1468-73
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi et al. 2000 J Clin Invest 105: 1827-1832

12/16/2025