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Tissue damage, associated with pathological conditions such as infection, cancer or autoimmunity, leads to the exposure of the intracellular content to the extracellular environment.
Myeloid cells detect ligands exposed or released by dead cells through specific receptors that signal for a diversity of responses.
Myeloid sensing of tissue damage may also dampen further injury by immunopathology
Tissue damage recognition by myeloid cells shapes immune responses
Any encounter with microbial products or tissue damage initiates migration of DC to lymph nodes
Shortman & Liu 2002
see also:
Myeloid Cells / Myelocytes