meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond

Claudins have a greater role in controlling the “pore pathway” or paracellular flux of ions and small molecules

Mitic et al. 2000 Am J Physiol Gastrointest Liver Physiol 279(2): G250-4
Van Itallie & Anderson 2004 Physiol (Bethesda) 19: 331-8
Van Itallie & Anderson 2014 Semin Cell Dev Biol 36: 157-65
König et al. 2016 Clin Transl Gastroenterol 7(10): e196
Ma et al. 2018a In: Physiology of the Gastrointestinal Tract: Sixth Edition. London, United Kingdom, San Diego, CA, United States, Cambridge, MA, United States, Kidlington, United Kingdom: Elsevier Inc 587-639. 1-2.

The family of claudin consists of 27 proteins and plays an important role in the maintenance of cell polarity and transportation, and are necessary for the strong binding of epithelial and endothelial cells

Niessen 2007 J Invest Dermatol 127: 25…