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Microglia are CNS-resident immune cells that respond to misfolded proteins through pattern recognition receptor ligation and activation of signal transduction pathways.
Internalization of Alfa-Synuclein (SNCA) monomers and oligomers activated the NLRP3 inflammasome via Toll-like receptor 2 (TLR-2) and [Toll-like receptor 5 (TLR-5)](brain://LhIOywcPMUmrLmbM_…