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Intestinal barrier dysfunction may allow toxins to move from the intestinal lumen into the bloodstream. This can lead to an increase in circulating lipopolysaccharides and trigger an innate immune response. Such processes are thought to be crucial in the development of Amyotrophic lateral sclerosis (ALS)
Elevated levels of endotoxin, specifically Lipopolysaccharides (LPS), were observed in the pl…