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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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NLRP3 Inflammasome

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NLRP3 Inflammasome

The NLRP3 Inflammasome is a distinctive polymer protein complex. It plays a crucial role in recognizing both endogenous and exogenous danger signals. Upon recognition, NLRP3 Inflammasome can induce inflammation through gasdermin D-dependent pyroptosis and the secretion of mature, bioactive forms of Interleukin-1 (IL-1) beta (IL-1F2) and Interleukin-18 (IL-18)
Mosley et al. 1987 J Biol Chem 262: 2941-2944
Li et al. 2024 The Journal of Immunology 213: 407-417

The NLRP3 inflammasome…

References (Sources)

Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner
Holtmann et al. 2021 Cell 10: 2618
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inﬂammasome activation by regulating NLRP3 expression
Bauernfeind et al. 2009 J Immunol 183: 787-791
FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inﬂammation After Binge or Prolonged Alcohol Feeding in Mice
Iracheta-Vellve et al. 2018 Hepatol. Commun. 2: 1379-1391
NLRP1B and NLRP3 Control the Host Response following Colonization with the Commensal Protist Tritrichomonas musculis
Chiaranunt et al. 2022 J Immunol 208: 1782-1789
Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia
Yang et al. 2018f J. Hepatol. 69: 1136-1144
The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor
Mosley et al. 1987 J Biol Chem 262: 2941-2944
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
Kelley et al. 2019 Int. J. Mol. Sci. 20: 3328
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Inflammasome - Wikipedia