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NLRP3 Inflammasome
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Contents
The NLRP3 Inflammasome is a distinctive polymer protein complex. It plays a crucial role in recognizing both endogenous and exogenous danger signals. Upon recognition, NLRP3 Inflammasome can induce inflammation through gasdermin D-dependent pyroptosis and the secretion of mature, bioactive forms of Interleukin-1 (IL-1) beta (IL-1F2) and Interleukin-18 (IL-18)
The NLRP3 inflammasome is essential in the genesis and progression o…
References (Sources)
- Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner
- Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
- FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice
- NLRP1B and NLRP3 Control the Host Response following Colonization with the Commensal Protist Tritrichomonas musculis
- NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
- Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation