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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) & Peptidoglycans (PGN)

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Bacterial peptidoglycans are recognized by NOD1 receptors through diaminopimelic acid sensing, an amino acid common in the cell wall of gram-negative and some gram-positive bacteria
Pardo-Camacho et al. 2018 Am J Physiol Gastrointest Liver Physiol 314: G247-G255

The most well-defined sensors of peptidoglycan are the cytosolic NOD-like receptors (NLRs), [NOD1](brain://rss_IxXN_F-mmM8lexJI9A/Nucleoti…

Dysbiosis and the immune system
Levy et al. 2017
Review
Epithelial immunity: priming defensive responses in the intestinal mucosa
Pardo-Camacho et al. 2018 Am J Physiol Gastrointest Liver Physiol 314: G247-G255
Review
Nod-like proteins in inflammation and disease
Carneiro et al., 2008
Review
Peptidoglycan recognition by the innate immune system
Wolf & Underhill 2018
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
Clarke et al. 2010 Nat Med 16: 228-231

5/29/2026