meRfi®-GM
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) & Peptidoglycans (PGN)
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Contents
Bacterial peptidoglycans are recognized by NOD1 receptors through diaminopimelic acid sensing, an amino acid common in the cell wall of gram-negative and some gram-positive bacteria
The most well-defined sensors of peptidoglycan are the cytosolic NOD-like receptors (NLRs), [NOD1](brain://rss_IxXN_F-mmM8lexJI9A/Nucleoti…
References (Sources)
- Dysbiosis and the immune systemReview
- Epithelial immunity: priming defensive responses in the intestinal mucosa
- Nod-like proteins in inflammation and diseaseReview
- Peptidoglycan recognition by the innate immune system
- Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity