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Sphingosine-1-phosphate (S1P) and its receptors have emerged as important targets in the treatment of inflammatory bowel disease (IBD). The S1P-S1PR signaling pathway plays a crucial role in regulating lymphocyte migration and intestinal inflammation.
Sphingosine-1-phosphate (S1P) interacts with Sphingosine-1-phosphate (S1P) receptors on lymphocytes, controlling their movement from lymphoid organs (such as the spleen and lymph nodes) into systemic circulation
Choden et al. 2022 Gastroenterol Hepatol (NY) 18(5):…