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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Pathogenic Th2 (Tpath2) cells

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Pathogenic Th2 (Tpath2) cell are central to the development of Inflammation / Inflammatory diseases
Nakayama et al. 2021 Int Immunol. 33(12): 699-704
Kokubo et al. 2022 Front Immunol. 13: 945063

They produce large amounts of Th2 cytokines (Interleukin-4 (IL-4), Interleukin-5 (IL-5), Interleukin-13 (IL-13)) and induce Type 2 inflammation upon activation by antigens or tissue injury

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References (Sources)

CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system
Nakayama et al. 2021 Int Immunol. 33(12): 699-704
Review
Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
Kokubo et al. 2022 Front Immunol. 13: 945063
Review
Functions and Clinical Applications of Extracellular Vesicles in TH2 Cell-Mediated Airway Inflammatory Diseases: A Review
Cheon et al. 2024 Int J Mol Sci. 25(17): 9455
Review

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12/16/2025

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Pathogenic Th2 (Tpath2) cells

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