meRfi®-GM
ST6GalNAc I sialyltransferase (ST6GALNAC1)
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Contents
ST6GalNAc I associated with increased sialylation of the abberant O-glycan Tn to Sialyl-Tn and associated with MUC1 expression
Biosynthesis of Sialyl-Tn (STn) / Neu5Acα2-6GalNAc-O-Ser/Thr is mediated by a specific sialyltransferase termed ST6GalNAc I
Julien et al., 2012
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References (Sources)
- Cloning and expression of a human gene encoding an N-acetylgalactosamine-α2,6sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens
- Correlation analysis between tumor-associated antigen sialyl-Tn expression and ST6GalNAc I activity in human colon adenocarcinoma
- Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
- Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA
- RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells
- Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
- ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues