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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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ST6GalNAc I sialyltransferase (ST6GALNAC1)

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ST6GalNAc I associated with increased sialylation of the abberant O-glycan Tn to Sialyl-Tn and associated with MUC1 expression

Biosynthesis of Sialyl-Tn (STn) / Neu5Acα2-6GalNAc-O-Ser/Thr is mediated by a specific sialyltransferase termed ST6GalNAc I
Julien et al., 2012

References (Sources)

Cloning and expression of a human gene encoding an N-acetylgalactosamine-α2,6sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens
Ikehara et al.1999
Correlation analysis between tumor-associated antigen sialyl-Tn expression and ST6GalNAc I activity in human colon adenocarcinoma
Vazquez-Martin et al., 2004
Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
Kvorjak et al. 2020 Cancer Immunology Research 8: 167
Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA
Julien et al. 2001
RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells
Tamura et al., 2016
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
Marcos et al., 2004
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues
Marcos et al. 2011 Front Biosci (EliteEd) 3: 1443–55

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ST6GALNAC1 - Wikipedia