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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Eggerthella lenta & Digoxin

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Digoxin inhibits RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) leading to decreased CD4+ Th17 Cells levels by directly binding to RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3)
Fujita-Sato et al. 2011 J. Biol. Chem. 286: 31409-31417
Huh et al. 2011 Nature 472: 486-490…

Chemical transformation of xenobiotics by the human gut microbiota
Koppel et al. 2017 Science 356: eaag2770
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgt activity
Huh et al. 2011 Nature 472: 486-490
Structural basis of digoxin that antagonizes RORgt receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production
Fujita-Sato et al. 2011 J. Biol. Chem. 286: 31409-31417

12/16/2025