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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Toll-like receptor 8 (TLR-8)

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What is TLR-8?

endosomal localisation

On which human immune cells is TLR-8 found?

myeloid dendritic cells (mDCs), T cells, Monocytes, NK cells
Shekarian et al. 2017 Ann Oncol. 28(8): 1756-1766

On which human non-immune cells is TLR-8 found?

What are the ligands of TLR-8?

The Toll-like receptor 8 (TLR8) is a critical sensor for viable bacteria, ssRNA viruses, and archaea in human antigen-presenting cells (APC).
Ugolini & Sander 2019

References (Sources)

Dead or alive: how the immune system detects microbial viability
Ugolini & Sander 2019
Review
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9
Heinz et al. 2020

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12/17/2025

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