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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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NLRP3 Inflammasome Activation

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Contents

Activators may cause relocalization to endosomal or Golgi compartments. The distinct changes in endosomal composition lead to the activation of the NLRP3 inflammasome. The activation of the NLRP3 inflammasome is mediated by PtdIns4P on the dispersed trans-Golgi network. The activation of NLRP3 and pyrin inflammasomes is mediated by Histone deacetylase 6 (HDAC6) through a mechanism similar to an aggresome.
Chen & Chen 2018 Nature 7734: 71-76
Magupalli et al. 2020 Science 369: eaas8995
Andreeva et al. 2021 Cell 184: 6299-6312
Neuwirt et al. 2021 Curr Opin Biotechnol 68: 300–309
Akbal et al. 2022 Cell Mol Immunol 19: 1201-1214
Zhang et al. 2023f Nat Immunol 24: 30-41

The mechanism of NLRP3 activation is complex and indistinct, including Kalium efﬂux, C…

References (Sources)

Gut-Liver Axis and Inﬂammasome Activation in Cholangiocyte Pathophysiology
Maroni et al. 2020 Cells 9: 736
Review
Inﬂammasome activation and function in liver disease
Szabo & Petrasek 2015 Nat. Rev. Gastroenterol. Hepatol. 12: 387-400
Review
Inﬂammasomes: mechanism of action, role in disease, and therapeutics
Guo et al. 2015a Nat Med 21: 677-687
Mitochondrial electron transport chain is necessary for NLRP3 inﬂammasome activation
Billingham et al. 2022 Nat Immunol 23: 692-704
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
Andreeva et al. 2021 Cell 184: 6299-6312
The calciumsensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
Lee et al. 2012 Nature 492: 123-127
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Swanson et al. 2019 Nat. Rev. Immunol. 19: 477-489

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