meRfi®-GM
NLRP3 Inflammasome Activation
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Activators may cause relocalization to endosomal or Golgi compartments. The distinct changes in endosomal composition lead to the activation of the NLRP3 inflammasome. The activation of the NLRP3 inflammasome is mediated by PtdIns4P on the dispersed trans-Golgi network. The activation of NLRP3 and pyrin inflammasomes is mediated by Histone deacetylase 6 (HDAC6) through a mechanism similar to an aggresome.
The mechanism of NLRP3 activation is complex and indistinct, including Kalium efflux, C…
References (Sources)
- Gut-Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology
- Inflammasome activation and function in liver disease
- Inflammasomes: mechanism of action, role in disease, and therapeutics
- Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
- NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
- The calciumsensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
- The NLRP3 inflammasome: molecular activation and regulation to therapeutics