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Many of the immediate triggers for neuronal cell death have been mentioned already and include: axotomy, aberrant cell-cycle reentry, glutamate excitotoxicity and oxytosis, loss of connected neurons, aggregated proteins, the unfolded protein response (UPR), lysosomal rupture, autophagy, oxidants, and macromolecular (DNA) damage.
Multiple Neurodegenerative Diseases (NDDs) hallmarks discussed are inducers of neuronal cell death and are expected to synergistically drive the neurodegenerative process
[Energy depletion](brain://q…