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Adherent-Invasive E. Coli (AIEC) have been suggested to play a pivotal role within the pathophysiology of Inflammatory Bowel Disease (IBD). Autoantibodies against distinct splicing variants of glycoprotein 2 (GP2), an intestinal receptor of the Bacterial Adhesin FimH, frequently occur in Inflammatory Bowel Disease (IBD) patients
Autoimmunity against intestinal expressed GP2 results in enhanced attachment o…