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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Fluorouracil (5-FU)

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Fluorouracil (5-FU) functions by inhibiting thymidylate synthase, disrupting nucleotide metabolism, and interfering with essential bacterial processes, such as quorum sensing. These actions contribute to its potential as an antimicrobial agent.
Niazy et al. 2025 Front Microbiol 16:1584479

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References (Sources)

Deciphering the Antibacterial Mechanisms of 5-Fluorouracil in Escherichia coli through Biochemical and Transcriptomic Analyses
Zhang et al. 2024c Antibiotics (Basel) 13(6): 528
Effect of 5-fluorouracil on Pseudomonas aeruginosa: impact on virulence, biofilm formation, and bacterial growth
Niazy et al. 2025 Front Microbiol 16:1584479
Review
Heat shock and HSP-70 regulate 5-FU- mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice
Pilot et al. 2020
On a New Proposed Mechanism of 5-Fluorouracil-Mediated Cytotoxicity
Hussain 2020 Trends in Cancer 6: 365
The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota
LaCourse et al. 2022 Cell Rep 41: 111625

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3/11/2026

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Fluorouracil (5-FU)

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