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Metastasis

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Tumor cells metastasize to distant organs through a complex series of events driven by both intrinsic and extrinsic factors. Among these, non-malignant stromal cells, including immune cells, play a significant role in modifying tumor metastatic behavior.
Güc & Pollard 2021 Immunity 54: 885-902

Particularly, tumor-associated innate immune cells, such as macrophages and neutrophils, are crucial in this process. These cells suppress the cytotoxic activity of both innate and adaptive killer cells and interact with tumor cells to promote their growth and malignancy.
Güc & Pollard 2021 Immunity 54: 885-902

see also:
[Blood vessels](brain://59KeszB14k61EZy4y1I…