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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Zinc Finger Protein Helios (IKFZ2)

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Zinc Finger Protein Helios is a crucial transcription factor belonging to the Ikaros family of zinc-finger proteins.

As a transcription factor, Helios can act as both an activator and repressor of gene expression
Hetemäki et al. 2021 medRxiv 2021.08.25.21262015

References (Sources)

Expression of Helios in peripherally induced Foxp3+ regulatory T cells
Gottschalk et al. 2012 J Immunol 188(3): 976-980
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
Thornton et al. 2010 J Immunol 184(7): 3433-3441
Helios expression is a marker of T cell activation and proliferation
Akimova et al. 2011 PLoS One 6(8): e24226
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Hetemäki et al. 2021 medRxiv 2021.08.25.21262015

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5/29/2026

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IKZF2 - Wikipedia