CD14 is expressed by various types of cells, primarily monocytes and monocyte-derived cells:
- Monocytes
CD14 ++ CD16 − Monocytes (classical monocytes)
CD14++ CD16+ Monocytes (intermediate monocytes)
CD14+ CD16++ Monocytes (non-classical monocytes)(?id=192c339f-e0fc-4ce2-8ae1-34a7ff35e0e6&linkText=CD14%2B+CD16%2B%2B+Monocytes)
- Monocyte-derived cells
Fibrocytes can express CD14
Monocyte-derived dendritic cells (mo-DCs) can express CD14
Monocyte-derived macrophages can express CD14
- Other cell types
certain subsets of dendritic cells
myeloid-derived suppressor cells (MDSCs)
Curnow et al. 2010 PLoS One 5(3): e9730
Bolzoni et al. 2017 Haematologica 102(4): 773-784
Monkley et al. 2020 PLoS One 15(12): e0243807
Ohkuma et al. 2023 Oncol Lett. 26(3): 381
CD14+ is expressed mainly by macrophages; CD14+ monocytes can differentiate into dendritic cells (DC), encouraged by cytokines, including GM-CSF & IL-4
For example, CD14, both a soluble and a membrane-bound protein, contributes to ligand delivery to various TLRs
Bezhaeva et al. 2022 Front. Cardiovasc. Med. 9: 820962
On its own, CD14 can act as a phagocytic receptor, but on macrophages, and dendritic cells it also acts as an accessory protein for TLR4
Murphy et al. 2022 W.W. Norton & Company ISBN 978-0-393-68093-5
