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Tryptophan metabolism
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Contents
Tryptophan follows three metabolic fates:
- Incorporation into proteins.
- Production of indoles.
- Breakdown into kynurenine.
Tryptophan is first deaminated to 3-indolepyruvate. It is then decarboxylated to indole acetaldehyde by indolepyruvate decarboxylase. This latter compound is transformed to tryptophol by alcohol dehydrogenase
Local tryptophan depletion through indoleamine pyrrole-2,3-dioxygenase (IDO)
Blankenstein et al. 2012
[IDO](brain://4pR9EoQgHUOoIsEafs9ZuQ/IdoIndolamine23…
References (Sources)
- Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis
- Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis
- Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis
- IDO expression by dendritic cells: tolerance and tryptophan catabolismReview
- Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
- Shenling Baizhu San ameliorates ulcerative colitis by regulating the gut microbiota and its tryptophan metabolites: A complementary medicine to mesalamine
- Tryptophan and indole metabolism in immune regulation